"Part of the difficulty many have with understanding Vitamin C
is that its benefits seem too many"
When using Vitamin C as a healing therapy the doses are much higher
than the daily recommended allowance!
Biological tissues that accumulate over 100 times the level in blood plasma of vitamin C are the adrenal glands, pituitary, thymus, corpus luteum, and retina. Those with 10 to 50 times the concentration present in blood plasma include the brain, spleen, lung, testicle, lymph nodes, liver, thyroid, small intestinal mucosa, leukocytes, pancreas, kidney and salivary glands.
Adrenal Glands/Adrenal Fatigue
The highest concentration of vitamin C in the body is stored in the adrenal glands. Vitamin C is utilized by the adrenal glands in the production of all of the adrenal hormones, most notably cortisol. When you are faced with a stressful situation, your vitamin C is rapidly used up in the production of cortisol and related stress-response hormones. In adrenal fatigue, your adrenal glands "panic" when they don't have enough vitamin C available, and, in what seems like an odd paradox, they release MORE cortisol. This not only increases your immediate anxiety, but as this state of high cortisol is prolonged, it wreaks havoc on your blood sugar, blood pressure, and contributes to the dreaded accumulation of belly fat. Source
In summary, our findings using both prevalence and incidence data from the large, population-based Cache County study suggest that antioxidant vitamins, specifically the combination of vitamin E and C supplements, may prevent AD. Formal demonstration of their efficacy would therefore have significant public health implications, and we suggest that prevention trials are warranted. JAMA
Treatment With Vitamin C Dissolves Toxic Protein Aggregates in Alzheimer's Disease. Researchers at Lund University have discovered a new function for vitamin C. Treatment with vitamin C can dissolve the toxic protein aggregates that build up in the brain in Alzheimer's disease. Science Daily
Megadoses (more than 100 mg/Kg body weight per day) of vitamin C were shown to markedly reduce autistic symptoms in a double blind placebo controlled study so any restriction of vitamin C needs to be carefully weighed against its significant benefits. Source
In a multivariate model controlling for other factors, a significant protective effect was found for vascular dementia in men who had reported taking both vitamin E and C supplements in 1988. These results suggest that vitamin E and C supplements may protect against vascular dementia and may improve cognitive function in late life. PubMed
We found that cells in the retina need to be 'bathed' in relatively high doses of vitamin C, inside and out, to function properly,” Nerve cells in the eye require vitamin C in order to function properly — a surprising discovery that may mean vitamin C is required elsewhere in the brain for its proper functioning, according to a study by scientists at Oregon Health & Science University recently published in the Journal of Neuroscience. OSHU
Study Results: Overall, reported flu and cold symptoms in the test group decreased 85% compared with the control group after the administration of megadose Vitamin C. Conclusion: Vitamin C in megadoses administered before or after the appearance of cold and flu symptoms relieved and prevented the symptoms in the test population compared with the control group. PubMed
Liver/Cirrhosis of the Liver
Vincent Zannoni at the University of Michigan Medical School has shown that vitamin C protects the liver. Even doses as low as 500 milligrams daily helps prevent fatty buildup and cirrhosis. 5,000 mg of vitamin C per day appears to actually flush fats from the liver. (Ritter, M. "Study Says Vitamin C Could Cut Liver Damage," Associated Press, October 11, 1986) And vitamin C over 50,000 mg/day (not a misprint) results in patients feeling better in just a few days, and actually eliminates jaundice in under a week. (Cathcart, Robert F. III (1981) The method of determining proper doses of vitamin C for the treatment of disease by titrating to bowel tolerance. Journal of Orthomolecular Psychiatry. 10:125-132.) Frederick Klenner, MD, found that such huge doses of vitamin C had his patients recovered and back to work in under a week. (Klenner, Frederick R. (1971). Source
Researchers conclude a high dietary intake of vitamin C or of foods rich in this vitamin may reduce the rate of loss of lung function in adults. This in turn may help to prevent chronic obstructive pulmonary disease. More and more studies are finding dietary factors play a key role in lung function. In particular, there is evidence that individuals with a high intake of vitamin C, A, and E tend to have higher levels of lung function. Source
The risk of pancreatic cancer declined significantly as intake of antioxidants increased among participants in a large case-control study. The magnitude of risk reduction varied by the quantity and types of antioxidants but reached a maximum of 67% in people who had the greatest intake of vitamins C and E and selenium. Treatment for pancreatic cancer with pharmacological ascorbate (ascorbic acid, vitamin C) decreases tumor progression in preclinical models. PubMed
To address questions of efficacy and drug-drug interaction, we tested 10 cancer cell lines with AA, GSH, and their combination. The results showed that pharmacologic AA induced cytotoxicity in all tested cancer cells. Pubmed
Our analysis suggested that the promiscuous oxidative actions of H(2)O(2) derived from pharmacologic ascorbate can culminate in synergism independent of the cancer cell's underlying phenotype and resistance to gemcitabine monotherapy. Gemcitabine-ascorbate combinations administered to mice bearing pancreatic tumor xenografts consistently enhanced inhibition of growth compared to gemcitabine alone, produced 50% growth inhibition in a tumor type not responsive to gemcitabine, and demonstrated a gemcitabine dose-sparing effect. These data support the testing of pharmacologic ascorbate in adjunctive treatments for cancers prone to high failure rates with conventional therapeutic regimens, such as pancreatic cancer. PubMed
There is compelling evidence suggesting an inverse relation between vitamin C intake and gastric cancer risk. Vitamin C is an important antioxidant and can react with nitrite, preventing the formation of N-nitroso compounds. The reduction in vitamin C concentrations in the stomach may have implications inH pylori associated carcinogenesis. GUT
Researchers studied whether taking vitamin C along with levothyroxine medications (i.e., Synthroid, Levoxyl, Levothroid, etc.) could affect TSH levels. The results were quite surprising. The research showed that taking vitamin C along with levothyroxine reduced TSH levels substantially, by as much as 27%. (*4)
There is compelling evidence suggesting an inverse relation between vitamin C intake and gastric cancer risk. Vitamin C is an important antioxidant and can react with nitrite, preventing the formation of N-nitroso compounds. (*5)
WHITE BLOOD CELLS/LEUCOCYTES:
Cells of the body that fight against infectious disease and foreign materials. Evidence is accumulating that AA plays an important role in immunocompetence and in the antioxidant defense system. Recent reports link vitamin C status with lymphocyte blastogenesis, antibody response to viral antigens, and circulating levels of the immunemodulators complement Clq and interleukin-1. New data also demonstrate the importance of AA as a plasma antioxidant, and the in vitro measurement of the ascorbate free radical as a clinical index of oxygen radical attack has been suggested. (*6)
Currently there are several studies showing promise in treating advanced pancreatic cancer with Vitamin C. The risk of pancreatic cancer declined significantly as intake of antioxidants increased among participants in a large case-control study. The magnitude of risk reduction varied by the quantity and types of antioxidants but reached a maximum of 67% in people who had the greatest intake of vitamins C and E and selenium.
The data suggested a threshold effect for selenium and a trend toward a threshold effect for vitamin E, as well as a significant inverse association between pancreatic cancer risk and serum levels of vitamin C. (*8)
Vitamin C and E supplementation saw a decrease in the elements that cause fibrosis, leading to considerably reduced glomerulosclerosis and kidney fibrosis. The study concluded “chronic antioxidant intervention in early experimental renovascular disease improves renal functional responses, enhances tissue remodeling, and decreases structural injury.” (*10) Dr. Levine suggested that the "upper safe doses of vitamin C are less than 1,000 mg daily in healthy people", although he noted that several earlier studies had not found any association between the incidence of kidney stones and the regular daily intake of 1,000 mg or more of vitamin C. (*9)